{"id":401,"date":"2016-11-24T15:34:30","date_gmt":"2016-11-24T06:34:30","guid":{"rendered":"https:\/\/www.org-synth.chem.sci.titech.ac.jp\/ohmorilab\/?page_id=401"},"modified":"2016-11-24T19:46:31","modified_gmt":"2016-11-24T10:46:31","slug":"development-of-new-synthetic-method-and-strategy","status":"publish","type":"page","link":"https:\/\/www.org-synth.chem.sci.titech.ac.jp\/?page_id=401","title":{"rendered":"Development of New Synthetic Method and Strategy"},"content":{"rendered":"<ul>\n<li><a href=\"#R001\">Stereospecific 1,2-rearrangement<\/a>\n<ul>\n<li>Pinacol-type rearrangement<\/li>\n<li>Epoxy alcohol-aldol rearrangement<\/li>\n<\/ul>\n<\/li>\n<li><a href=\"#R002\">Highly efficient glycosidation (metallocene method)<\/a><\/li>\n<li><a href=\"#R003\">Cyclopropane formation<\/a><\/li>\n<li><a href=\"#R004\">New efficient method for &#8220;benzyne&#8221; generation<\/a><\/li>\n<li><a href=\"#R005\">Cycloadditions of benzyne<\/a><\/li>\n<li><a href=\"#R006\">Aryl C-glycosidation reaction (<em>O<\/em>\u2192<em>C<\/em>-glycoside rearrangement)<\/a><\/li>\n<li><a href=\"#R007\">Chemistry of strained molecules 1<\/a>\n<ul>\n<li>Double bond insertion (C=O)<\/li>\n<li>Double Bond insertion (C=C)<\/li>\n<li>Oxygene insertion (synthesis of phthalides)<\/li>\n<\/ul>\n<\/li>\n<li><a href=\"#R008\">Chemistry of Strained molecules 2<\/a>\n<ul>\n<li>S<sub>N<\/sub>2&#8242; reaction<\/li>\n<li>Synthesis of biphenyl derivatives ([4+2])<\/li>\n<li>Synthesis of cyclooctadiene derivatives ([4+2+2])<\/li>\n<\/ul>\n<\/li>\n<li><a href=\"#R009\">Pinacol cyclization<\/a><\/li>\n<li><a href=\"#R010\">Group-selective hydroalumination<\/a><\/li>\n<li><a href=\"#R011\">Chemistry of flavonoids<\/a><\/li>\n<li><a href=\"#R012\">Enzyme-catalyzed reactions<\/a>\n<ul>\n<li>cyclohexanetriol<\/li>\n<li>axially chiral biaryl<\/li>\n<\/ul>\n<\/li>\n<li><a href=\"#R013\">Carbometalation using zirconocene reagent<\/a>\n<ul>\n<li>Reductive Coupling of alkenes with allens<\/li>\n<li>Allylmetalation of alkynes<\/li>\n<li>Alkylmetalation of alkynes<\/li>\n<\/ul>\n<\/li>\n<li><a href=\"#R014\">Cyclocondensation of stable benzonitrile oxides with 1,3-diketones<\/a><\/li>\n<li><a href=\"#R015\">Aldehyde\u2013ketone benzoin cyclization<\/a><\/li>\n<li><a href=\"#R016\">Formation of spiroisoquinoline framework<\/a><\/li>\n<\/ul>\n<hr \/>\n<h2 id=\"R001\">Stereospecific 1,2-rearrangement<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R001-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R002\">Highly efficient glycosidation (metallocene method)<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R002-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R003\">Cyclopropane formation<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R003-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R004\">New efficient method for &#8220;benzyne<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R004-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R005\">Cycloadditions of benzyne<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R005-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R006\">Aryl C-glycosidation reaction (<em>O<\/em>\u2192<em>C<\/em>-glycoside rearrangement)<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R006-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R007\">Chemistry of strained molecules 1<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R007-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R008\">Chemistry of Strained molecules 2<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R008-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R009\">Pinacol cyclization&lt;<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R009-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R010\">Group-selective hydroalumination<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R010-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R011\">Chemistry of flavonoids<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R011-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R012\">Enzyme-catalyzed reactions<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R012-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R013\">Carbometalation using zirconocene reagent<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R013-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R014\">Cyclocondensation of stable benzonitrile oxides with 1,3-diketones<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R014-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R015\">Aldehyde\u2013ketone benzoin cyclization<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R015-e.png\" alt=\"\" \/><\/figure>\n<h2 id=\"R016\">Formation of spiroisoquinoline framework<\/h2>\n<figure class=\"center\"><img decoding=\"async\" src=\"\/ohmorilab\/wp-content\/themes\/org-synth\/image\/reactions-e\/R016-e.png\" alt=\"\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Stereospecific 1,2-rearrangement Pinacol-type rearrangement Epoxy alcohol-aldol rearrangement Highly efficient [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-e.php","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-401","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.org-synth.chem.sci.titech.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/401","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.org-synth.chem.sci.titech.ac.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.org-synth.chem.sci.titech.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.org-synth.chem.sci.titech.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.org-synth.chem.sci.titech.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=401"}],"version-history":[{"count":14,"href":"https:\/\/www.org-synth.chem.sci.titech.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/401\/revisions"}],"predecessor-version":[{"id":416,"href":"https:\/\/www.org-synth.chem.sci.titech.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/401\/revisions\/416"}],"wp:attachment":[{"href":"https:\/\/www.org-synth.chem.sci.titech.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}