天然物の全合成
当研究室では天然有機化合物の全合成に挑戦しています。合成目標とする化合物の中には、天然から僅かしか得られない希少なもの、有用かつ強力な生理活性を持つもの、あるいは珍しい構造をもつもの、ときには非常に不安定で取り扱いにくいものなどもあります。我々は、既存の方法論の組み合せでは合成困難、あるいは非常に手間がかかる化合物を積極的に取り挙げ、その全合成に挑戦しています。それらをどのような作戦で効率的かつ選択的に作り上げるか。そこが我々の腕の見せ所ともいえます。以下には、これまで私たちが行ってきた天然物合成の一例を示しました。どれも自身作です。是非ご覧下さい。
- mycinamicin IV
- vineomycinone B2
- aquayamycin
- avenaciolide
- fraquinocins
- galtamycinone
- gilvocarcins
- C104 antibiotic
- eicosanoid
- methylerysodienone
- procyanidins
- lotthanongine
- malyngolide
- seragakinone A
- BE-43472B
- saptomycin B
- cavicularin
- cinnamtannin B1
Total Synthesis of Mycinamicin IV
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/mycinamicin.png)
Total Synthesis of Vineomycinone B2
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/vineomycinoneB2.png)
Total Synthesis of Aquayamycin
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/aquayamycin.png)
Total Synthesis of Avenaciolide
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/avenaciolide.png)
Total Syntheses of Fraquinocins
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/fraquinocins.png)
Total Synthesis of Galtamycinone
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/galtamycinone.png)
Total Syntheses of Gilvocarcins
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/gilvocarcins.png)
Total Synthesis of C104 antibiotic
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/C104.png)
Total Synthesis of a Marine Eicosanoid
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/eicosanoid.png)
Total Synthesis of Methylerysodienone
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/methylerysodienone.png)
Total Synthesis of Procyanidin
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/procyanidin.png)
Total Synthesis of Lotthanongine
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/lotthanongine.png)
Total Synthesis of Malyngolide
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/malyngolide.png)
Total Synthesis of Seragakinone A
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/seragakinone.png)
[212] A. Takada, Y. Hashimoto, K. Hikita, H. Takikawa, and K. Suzuki. Angew. Chem. Int. Ed. 2011, 50, 2297.
Total Synthesis of BE-43472B
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/BE43472B.png)
[232] Y. Yamashita, Y. Hirano, A. Takada, H. Takikawa, K. Suzuki. Angew. Chem. Int. Ed. 2013, 52, 6658.
Total Synthesis of Saptomycin B
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/saptomycinB.png)
Total Synthesis of Cavicularin
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/cavicularin.png)
[233] H. Takiguchi, K. Ohmori, K. Suzuki, Angew. Chem. Int. Ed. 2013, 52, 10472.
Total Synthesis of Cinnamtannin B1
![](/ohmorilab/wp-content/themes/org-synth/image/total-synth/cinnamtanninB1.png)
[237] Y. Ito, K. Ohmori, K. Suzuki, Angew. Chem. Int. Ed. 2014, 53, 10129.